Transferability of the mcr-1 Colistin Resistance Gene
نویسندگان
چکیده
منابع مشابه
Features of the mcr-1 Cassette Related to Colistin Resistance.
Katrin Zurfluh, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann, Roger Stephan Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Switzerland; Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (LEA Paris, France), University of Fribourg, Fribourg, Swi...
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Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem-resistant bacteria. Very recently, a new plasmid-borne colistin resistance g...
متن کاملDissemination and Mechanism for the MCR-1 Colistin Resistance
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomi...
متن کاملThe Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)
Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ec...
متن کاملmcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France
We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.
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ژورنال
عنوان ژورنال: Microbial Drug Resistance
سال: 2017
ISSN: 1076-6294,1931-8448
DOI: 10.1089/mdr.2016.0191